Seminar #1 - 11 February
Ferroptosis: from metabolism to disease treatment
15:00-15:10
15:10-15:40
15:40-16:10
Targeting Ferroptosis for the Treatment of as-yet-Incurable Diseases
(Helmholtz Zentrum München, Germany)

16:10-17:00
Questions and Answers
Questions and Answers
Seminar #2 - 11 March
Redox therapies for neurodegenerative diseases: lights and shadows
15:00-15:10
Welcome and Introduction
Luciano Saso view bio
(Faculty of Pharmacy and Medicine, Sapienza University of Rome)
15:10-15:30
The NRF2-KEAP1 Signaling Pathway as a Pharmacological Target in Neurodegenerative diseases read abstract
Antonio Cuadrado view bio
(Dept of Biochemistry, Medical School, Autonomous University of Madrid, Spain)

15:30-15:50
Breaking the vicious cycle of oxidative stress – inflammation – cell death by reversible cysteine modifications of Keap1 read abstract
Albena T. Dinkova-Kostova view bio
(Jacqui Wood Cancer Centre, Division of Cellular Medicine, School of Medicine, University of Dundee, UK)

15:50-16:10
Oxidative Stress in Amyotrophic Lateral Sclerosis: Pathophysiology and Opportunities for Pharmacological Intervention read abstract
Paulo J. Oliveira view bio
(CNC-Center for Neuroscience and Cell Biology, University of Coimbra, UC Biotech Building, Biocant Park, Cantanhede, Portugal)

16:10-17:00
Questions and Answers
Questions and Answers
Seminar #3 - 26 April
Crosstalk between oxidative stress and metabolic defects: implications for Alzheimer's disease
15:00-15:10
Welcome and Introduction
Luciano Saso view bio
(Faculty of Pharmacy and Medicine, Sapienza University of Rome)
15:10-15:40
Amyloid β-peptide and brain oxidative damage: focus on the intersection of the lipid peroxidation product HNE covalently bound to brain proteins, glucose dysmetabolism, and Alzheimer disease read abstract
D. Allan Butterfield view bio
(Dept of Chemistry and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA)

15:40-16:00
Mitochondrial dysfunction and oxidative stress in Alzheimer’s disease read abstract
Paula I. Moreira view bio
(Institute of Physiology, Faculty of Medicine, Center for Neuroscience and Cell Biology, University of Coimbra, Portugal)

16:00-16:20
Down Syndrome is a metabolic disease: altered insulin signaling mediates brain dysfunctions read abstract
Marzia Perluigi view bio
(Dept of Biochemical Sciences, Sapienza University of Rome, Italy)

16:20-17:00
Questions and Answers
Questions and Answers
Seminar #4 - 13 May
Radioprotectors and radiosensitizers in cancer therapy
15:00-15:10
Welcome and Introduction
Luciano Saso view bio
(Faculty of Pharmacy and Medicine, Sapienza University of Rome)
15:10-15:30
Targeting Redox Metabolism for Cancer Therapy: From the Bench to the Bedside read abstract
Douglas R. Spitz view bio
(Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA, USA)

15:30-15:50
SOD mimics act as a radiosensitizer by enhancing hydrogen peroxide levels and altering metabolism in prostate cancer cells read abstract
Rebecca Oberley-Deegan view bio
(Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA)

15:50-16:10
Advancing Redox Principles and Chemistry for Diagnosis and Treatment of Radiation Resistant Cancer read abstract
Cristina M. Furdui view bio
(Department of Internal Medicine, and Co-Director of the Center for Redox Biology and Medicine at Wake Forest School of Medicine, Winston-Salem, NC, USA)

16:10-17:00
Questions and Answers
Questions and Answers
Seminar #5 - 24 June
Therapeutic potential of antioxidants: from male infertility to retinal disorders
15:00-15:10
15:10-15:40
Oxidative stress and antioxidant-based therapies in male infertility read abstract
Barbara Tavazzi view bio
(Catholic University of Rome, Italy)

15:40-16:10
A glance on antioxidants: the role of sulfur amino acids in retinal disorders read abstract
Marcello Allegretti view bio
(Dompè, L’Aquila, Italy)

16:10-17:00
Questions and Answers
Questions and Answers
Seminar #6 - 6 July
Interplay between the gaseous signaling molecules NO and H2S: from reaction mechanisms to physiology
15:00-15:10
15:10-15:40
The reactive species interactome in health and disease
Martin Feelisch view bio
(University of Southampton, United Kingdom)

15:40-16:05
The H2S/NO crosstalk at the level of the H2S-synthesizing enzymes read abstract
João B. Vicente view bio
(Universidade Nova de Lisboa, Portugal)

16:05-16:30
The redox physiology and pharmacology of the interaction of sulfide and nitric oxide in the cardiovascular system read abstract
Miriam Cortese-Krott view bio
(University of Dusseldorf, Germany)

16:30-17:00
Questions and Answers
Questions and Answers
Seminar #7 - 7 September
Redox balance, metabolism and aggressiveness of cancer cells
15:00-15:10
15:10-15:40
Mitochondrial Redox Hubs as Promising Targets for Anticancer Therapy read abstract
Paola Chiarugi view bio
(University of Florence, Italy)

15:40-16:10
Targeting NF-κB downstream effectors in cancer: embracing complexity to treat disease read abstract
Daria Capece view bio
(University of L’Aquila, Italy)

16:10-17:00
Questions and Answers
Questions and Answers
Seminar #8 - 4 October
Exercise and disease prevention: the role of redox signaling
15:00-15:10
Welcome and Introduction
Luciano Saso view bio
(Faculty of Pharmacy and Medicine, Sapienza University of Rome)
15:10-15:30
Muscle redox responses to exercise and ageing read abstract
Malcolm J. Jackson view bio
(MRC-Versus Arthritis Centre for Integrated research into Musculoskeletal Ageing, Dept of Musculoskeletal and Ageing Science, Inst. of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK)

15:30-15:50
Redox regulation of muscle function in exercise read abstract
Mari Carmen Gomez-Cabrera view bio
(Freshage Research Group, Dept Physiology, University of Valencia, CIBERFES, INCLIVA, Valencia, Spain)

15:50-16:10
Exercise, oxidative eustress and stress response read abstract
Daniela Caporossi view bio
(Unit of Biology and Genetics of Human Movement, Department of Movement, Human and Health Sciences, University of Rome Foro Italico, Rome, Italy)

16:10-17:00
Questions and Answers
Questions and Answers
Seminar #9 - 14 October
The gaseous signaling molecules NO, CO and H2S as new old players in the prokaryotic world
15:30-15:40
15:40-16:20
Nitric oxide, carbon monoxide and hydrogen sulfide: a microbial perspective of the trinity read abstract
Robert K. Poole view bio
(University of Sheffield, Sheffield, UK)

16:20-17:00
Role of H2S in Mycobacterium tuberculosis pathogenesis: a new paradigm for understanding dormancy read abstract
Adrie J.C. Steyn view bio
(Africa Health Research Institute, Durban, South Africa & University of Alabama, Birmingham, AL, USA)

17:00-17:30
Questions and Answers
Questions and Answers
Seminar #10 - 18 November
Pharmacological perspectives from investigation of the gasotransmitter hydrogen sulfide in Down syndrome and Alzheimer's disease
15:00-15:10
15:10-15:50
The CBS/H2S system: a re-emerging therapeutic target in Down syndrome read abstract
Csaba Szabo view bio
(University of Fribourg, Switzerland)

15:50-16:30
Protective role of Sulfhydration in Alzheimer’s disease read abstract
Bindu D. Paul view bio
(Johns Hopkins University, Baltimore, MD, USA)

16:30-17:00
Questions and Answers
Questions and Answers
Seminar #11 - 2 December
Metabolic ROS production and resolution of inflammation: new perspectives for anticancer treatments
15:00-15:10
15:10-15:50
Modulation of cancer cell proliferation by interfering with metabolic ROS production: new perspective for anticancer treatments read abstract
Maria Rosa Ciriolo view bio
(Tor Vergata University of Rome, Italy)

15:50-16:30
Proresolving lipid mediators as novel endogenous modulators of oxidative stress read abstract
Alessandro Leuti view bio
(Campus Bio-Medico University of Rome, Italy)

16:30-17:00
Questions and Answers
Questions and Answers
Seminar #12 - 16 December
Aberrant redox responses in neurodevelopmental conditions: the case of autism and Rett Syndrome
15:00-15:10
Welcome and Introduction
Luciano Saso view bio
(Faculty of Pharmacy and Medicine, Sapienza University of Rome)
15:10-15:30
OxInflammation in Rett Syndrome read abstract
Giuseppe Valacchi view bio
(Department of Neuroscience and Rehabilitation, University of Ferrara, Italy)

15:30-15:50
Deciphering the role of cerebral redox imbalance in Rett Syndrome read abstract
Michael Müller view bio
(University Medical Center Göttingen, Inst. Neuro- and Sensory Physiology, Göttingen, Germany)

15:50-16:10
Mitochondrial impairment in Autism Spectrum Disorders read abstract
Alessandra Pecorelli view bio
(North Carolina State University, Animal Science Dept., Plants for Human Health Institute, Kannapolis, NC, USA)

16:10-17:00
Questions and Answers
Questions and Answers